Semax Reconstitution Calculator

What is Semax?

Semax is a synthetic heptapeptide analog corresponding to a modified version of the 4-10 fragment of adrenocorticotropic hormone (ACTH), developed in Russia. It lacks the classic adrenocortical-stimulating activity of the parent hormone. Published research — primarily from Russian laboratories — has studied Semax in animal and human research contexts involving cognitive performance, neuroprotection, and recovery after ischemic events. Semax has been registered as a pharmaceutical in Russia but is not approved by the FDA in the United States. Research-grade Semax is labeled for laboratory use only.

Common vial sizes

Research vendors typically offer Semax in 5 mg, 10 mg, or 30 mg lyophilized vials. Reconstitution with 2–5 mL of bacteriostatic water is commonly reported.

• 5 mg vial
• 10 mg vial
• 30 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 10 mg vial + 2 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 500 mcg dose = 10 units on a u-100 insulin, 1 ml (100 units) (0.1 mL).
• 10 mg vial + 3 mL bacteriostatic water → 3333.33 mcg/mL concentration.
  A 1000 mcg dose = 30 units on a u-100 insulin, 1 ml (100 units) (0.3 mL).
• 30 mg vial + 5 mL bacteriostatic water → 6000 mcg/mL concentration.
  A 1000 mcg dose = 16.7 units on a u-100 insulin, 1 ml (100 units) (0.167 mL).
• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 500 mcg dose = 20 units on a u-100 insulin, 1 ml (100 units) (0.2 mL).

Storage & shelf life

Lyophilized Semax is typically stored refrigerated. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published work reports a short plasma half-life for unmodified Semax, though downstream neurochemical effects measured in research have been reported to extend beyond the circulating half-life.