CJC-1295 with DAC Reconstitution Calculator

What is CJC-1295 with DAC?

CJC-1295 with DAC is a long-acting analog of growth hormone releasing hormone (GHRH) that incorporates a drug affinity complex (DAC) — a maleimide functional group that covalently binds circulating albumin. Published pharmacokinetic research reports that this albumin binding dramatically extends the molecule’s plasma half-life compared to native GHRH or the no-DAC variant. It has been studied for its effect on sustained, rather than pulsatile, growth hormone release. CJC-1295 with DAC is not approved by the FDA for human use. Research-grade material is sold as a laboratory reagent only.

Common vial sizes

Research vendors typically offer CJC-1295 with DAC in 2 mg or 5 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

• 2 mg vial
• 5 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 500 mcg dose = 50 units on a u-100 insulin, 1 ml (100 units) (0.5 mL).
• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 1000 mcg dose = 100 units on a u-100 insulin, 1 ml (100 units) (1 mL).
• 5 mg vial + 3 mL bacteriostatic water → 1666.67 mcg/mL concentration.
  A 1000 mcg dose = 60 units on a u-100 insulin, 1 ml (100 units) (0.6 mL).
• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 2000 mcg dose = 200 units on a u-100 insulin, 1 ml (100 units) (2 mL).

Storage & shelf life

Lyophilized CJC-1295 with DAC is typically stored refrigerated or frozen for long-term storage. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published pharmacokinetic studies report a plasma half-life of approximately 8 days for CJC-1295 with DAC, attributed to the covalent albumin binding.