Sermorelin Reconstitution Calculator

What is Sermorelin?

Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of growth hormone releasing hormone (GHRH). Published research has studied its action at the GHRH receptor on anterior pituitary somatotrophs and its effect on endogenous growth hormone release. Sermorelin was previously approved by the FDA as a diagnostic agent for assessing pituitary function (brand name Geref) before being discontinued as a prescription product. It has subsequently been available from compounding pharmacies and sold by research chemical vendors. Research-grade sermorelin is labeled for laboratory use only.

Common vial sizes

Research vendors typically offer sermorelin in 2 mg, 5 mg, 10 mg, or 15 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

• 2 mg vial
• 5 mg vial
• 10 mg vial
• 15 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 200 mcg dose = 8 units on a u-100 insulin, 1 ml (100 units) (0.08 mL).
• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 500 mcg dose = 20 units on a u-100 insulin, 1 ml (100 units) (0.2 mL).
• 10 mg vial + 3 mL bacteriostatic water → 3333.33 mcg/mL concentration.
  A 500 mcg dose = 15 units on a u-100 insulin, 1 ml (100 units) (0.15 mL).
• 15 mg vial + 3 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 1000 mcg dose = 20 units on a u-100 insulin, 1 ml (100 units) (0.2 mL).

Storage & shelf life

Lyophilized sermorelin is typically stored refrigerated at 2–8 °C. Reconstituted solutions are commonly kept refrigerated and protected from light; published stability data for compounded sermorelin typically references a multi-week window under refrigeration.

Reported half-life

Published pharmacokinetic studies report a short plasma half-life of approximately 10–20 minutes for sermorelin.