Sermorelin Calculator

Sermorelin dosage calculator

The Sermorelin dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. Sermorelin is commonly sold in 2 mg, 5 mg, 10 mg, 15 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A 29-amino-acid truncated GHRH analog that binds pituitary GHRH receptors to stimulate endogenous growth hormone release. Enter your target dose in the calculator above to see the exact number of units to draw.

Sermorelin dosage chart

Sermorelin and GHRH peptides

Sermorelin is a Truncated GHRH (1-29) analog. A 29-amino-acid truncated GHRH analog that binds pituitary GHRH receptors to stimulate endogenous growth hormone release. The same molecule is the active ingredient in Geref, which are FDA-approved prescription medications manufactured by their respective companies. Research-use Sermorelin is regulated differently and is not approved for human consumption. Other peptides in the GHRH class include CJC-1295 (no DAC) , CJC-1295 with DAC , and Tesamorelin .

Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of growth hormone releasing hormone (GHRH). Published research has studied its action at the GHRH receptor on anterior pituitary somatotrophs and its effect on endogenous growth hormone release. Sermorelin was previously approved by the FDA as a diagnostic agent for assessing pituitary function (brand name Geref) before being discontinued as a prescription product. It has subsequently been available from compounding pharmacies and sold by research chemical vendors. Research-grade sermorelin is labeled for laboratory use only.

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How to reconstitute Sermorelin

Research vendors typically offer sermorelin in 2 mg, 5 mg, 10 mg, or 15 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

Reconstituting Sermorelin is the same unit-conversion process used for any lyophilized peptide:

1. Draw your chosen volume of bacteriostatic water into a syringe.
2. Inject the bacteriostatic water slowly down the side of the Sermorelin vial — do not shoot it directly onto the powder.
3. Swirl gently until the powder fully dissolves. Do not shake.
4. Store the reconstituted vial refrigerated.
5. To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.

For Sermorelin specifically, 2 mg, 5 mg, 10 mg, 15 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 5 mg/mL for the 10 mg vial size.

Sermorelin half-life and storage

Published pharmacokinetic studies report a short plasma half-life of approximately 10–20 minutes for sermorelin.

Lyophilized sermorelin is typically stored refrigerated at 2–8 °C. Reconstituted solutions are commonly kept refrigerated and protected from light; published stability data for compounded sermorelin typically references a multi-week window under refrigeration.

Common Sermorelin dosing mistakes

Most Sermorelin draw errors are unit errors, not arithmetic errors: confusing mg with mcg (1 mg = 1,000 mcg), or reading a U-40 syringe with U-100 math — the same printed mark holds 2.5× the volume. Two more worth avoiding: leaving the vial unlabeled, so the concentration and reconstitution date are lost, and under-diluting to the point where the draw is under about one unit and can no longer be read accurately.

Each of these is covered in full in the guides: reconstitution math from first principles, U-100 vs U-40 syringes, storage and shelf life, and how to reconstitute peptides.