DSIP Calculator

DSIP dosage calculator

The DSIP dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. DSIP is commonly sold in 2 mg, 5 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A nine-amino-acid peptide originally isolated from cerebral venous blood, studied for its role in sleep and stress-response mechanisms. Enter your target dose in the calculator above to see the exact number of units to draw.

DSIP dosage chart

DSIP and Sleep peptides

DSIP is a Delta sleep-inducing peptide (nonapeptide). A nine-amino-acid peptide originally isolated from cerebral venous blood, studied for its role in sleep and stress-response mechanisms.

DSIP (delta sleep-inducing peptide) is a naturally occurring nine-amino-acid peptide first isolated from the cerebral venous blood of sleeping rabbits in the 1970s. Published research has studied DSIP in animal and limited human models of sleep regulation, stress response, and circadian biology, though the literature is older and mechanism remains incompletely characterized. DSIP is not approved by the FDA for human use. Research-grade DSIP sold by chemical supply companies is labeled for laboratory research only.

See all Sleep peptides →

How to reconstitute DSIP

Research vendors typically offer DSIP in 2 mg or 5 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

Reconstituting DSIP is the same unit-conversion process used for any lyophilized peptide:

1. Draw your chosen volume of bacteriostatic water into a syringe.
2. Inject the bacteriostatic water slowly down the side of the DSIP vial — do not shoot it directly onto the powder.
3. Swirl gently until the powder fully dissolves. Do not shake.
4. Store the reconstituted vial refrigerated.
5. To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.

For DSIP specifically, 2 mg, 5 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 2.5 mg/mL for the 5 mg vial size.

DSIP half-life and storage

Published pharmacokinetic studies report a very short plasma half-life for the DSIP parent peptide, on the order of 7 minutes in some reports, with downstream physiological effects measured to persist beyond the circulating half-life.

Lyophilized DSIP is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Common DSIP dosing mistakes

Most DSIP draw errors are unit errors, not arithmetic errors: confusing mg with mcg (1 mg = 1,000 mcg), or reading a U-40 syringe with U-100 math — the same printed mark holds 2.5× the volume. Two more worth avoiding: leaving the vial unlabeled, so the concentration and reconstitution date are lost, and under-diluting to the point where the draw is under about one unit and can no longer be read accurately.

Each of these is covered in full in the guides: reconstitution math from first principles, U-100 vs U-40 syringes, storage and shelf life, and how to reconstitute peptides.