Melanotan-2 Calculator

Melanotan-2 dosage calculator

The Melanotan-2 dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. Melanotan-2 is commonly sold in 10 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A synthetic cyclic heptapeptide analog of alpha-MSH that binds to melanocortin receptors including MC1R, MC3R, MC4R, and MC5R. Enter your target dose in the calculator above to see the exact number of units to draw.

Melanotan-2 dosage chart

Melanotan-2 and Melanocortin peptides

Melanotan-2 is a Synthetic melanocortin agonist. A synthetic cyclic heptapeptide analog of alpha-MSH that binds to melanocortin receptors including MC1R, MC3R, MC4R, and MC5R. Other peptides in the Melanocortin class include PT-141 (Bremelanotide) .

Melanotan-2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). It has been studied in published research as a non-selective melanocortin receptor agonist with binding affinity across the MC1R, MC3R, MC4R, and MC5R receptors. The literature has investigated MT-2 for its effects on melanogenesis as well as sexual function, the latter driven by its MC4R activity. Melanotan-2 is not approved by the FDA or other major regulators for human use. Research-grade Melanotan-2 sold by chemical supply companies is labeled for laboratory research only. Public health authorities in several countries have issued warnings about unregulated use of this compound.

See all Melanocortin peptides →

How to reconstitute Melanotan-2

Research vendors typically offer Melanotan-2 in 10 mg lyophilized vials. Reconstitution with 2–5 mL of bacteriostatic water is commonly reported.

Reconstituting Melanotan-2 is the same unit-conversion process used for any lyophilized peptide:

1. Draw your chosen volume of bacteriostatic water into a syringe.
2. Inject the bacteriostatic water slowly down the side of the Melanotan-2 vial — do not shoot it directly onto the powder.
3. Swirl gently until the powder fully dissolves. Do not shake.
4. Store the reconstituted vial refrigerated.
5. To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.

For Melanotan-2 specifically, 10 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 5 mg/mL for the 10 mg vial size.

Melanotan-2 half-life and storage

Published pharmacokinetic data reports a plasma half-life on the order of hours for Melanotan-2.

Lyophilized Melanotan-2 is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Common Melanotan-2 dosing mistakes

Most Melanotan-2 draw errors are unit errors, not arithmetic errors: confusing mg with mcg (1 mg = 1,000 mcg), or reading a U-40 syringe with U-100 math — the same printed mark holds 2.5× the volume. Two more worth avoiding: leaving the vial unlabeled, so the concentration and reconstitution date are lost, and under-diluting to the point where the draw is under about one unit and can no longer be read accurately.

Each of these is covered in full in the guides: reconstitution math from first principles, U-100 vs U-40 syringes, storage and shelf life, and how to reconstitute peptides.