Melanotan-2 Reconstitution Calculator

What is Melanotan-2?

Melanotan-2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). It has been studied in published research as a non-selective melanocortin receptor agonist with binding affinity across the MC1R, MC3R, MC4R, and MC5R receptors. The literature has investigated MT-2 for its effects on melanogenesis as well as sexual function, the latter driven by its MC4R activity. Melanotan-2 is not approved by the FDA or other major regulators for human use. Research-grade Melanotan-2 sold by chemical supply companies is labeled for laboratory research only. Public health authorities in several countries have issued warnings about unregulated use of this compound.

Common vial sizes

Research vendors typically offer Melanotan-2 in 10 mg lyophilized vials. Reconstitution with 2–5 mL of bacteriostatic water is commonly reported.

• 10 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 10 mg vial + 2 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 250 mcg dose = 5 units on a u-100 insulin, 1 ml (100 units) (0.05 mL).
• 10 mg vial + 5 mL bacteriostatic water → 2000 mcg/mL concentration.
  A 500 mcg dose = 25 units on a u-100 insulin, 1 ml (100 units) (0.25 mL).
• 10 mg vial + 3 mL bacteriostatic water → 3333.33 mcg/mL concentration.
  A 1000 mcg dose = 30 units on a u-100 insulin, 1 ml (100 units) (0.3 mL).
• 10 mg vial + 5 mL bacteriostatic water → 2000 mcg/mL concentration.
  A 1000 mcg dose = 50 units on a u-100 insulin, 1 ml (100 units) (0.5 mL).

Storage & shelf life

Lyophilized Melanotan-2 is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published pharmacokinetic data reports a plasma half-life on the order of hours for Melanotan-2.