5-Amino-1MQ Reconstitution Calculator

What is 5-Amino-1MQ?

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is not a peptide but is commonly sold alongside peptide products. Published research has studied 5-amino-1MQ in cell and animal models of adipocyte metabolism, NAD+ homeostasis, and white adipose tissue biology, based on the premise that NNMT inhibition can increase intracellular NAD+ availability. 5-Amino-1MQ is not approved by the FDA for human use. Research-grade material is sold only as a laboratory reagent.

Common vial sizes

Research vendors typically offer 5-amino-1MQ in 50 mg or 100 mg lyophilized vials. Reconstitution with 2–5 mL of bacteriostatic water is commonly reported for injectable research preparations.

• 50 mg vial
• 100 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 50 mg vial + 2 mL bacteriostatic water → 25000 mcg/mL concentration.
  A 5000 mcg dose = 20 units on a u-100 insulin, 1 ml (100 units) (0.2 mL).
• 50 mg vial + 3 mL bacteriostatic water → 16666.67 mcg/mL concentration.
  A 10000 mcg dose = 60 units on a u-100 insulin, 1 ml (100 units) (0.6 mL).
• 100 mg vial + 5 mL bacteriostatic water → 20000 mcg/mL concentration.
  A 10000 mcg dose = 50 units on a u-100 insulin, 1 ml (100 units) (0.5 mL).
• 100 mg vial + 3 mL bacteriostatic water → 33333.33 mcg/mL concentration.
  A 15000 mcg dose = 45 units on a u-100 insulin, 1 ml (100 units) (0.45 mL).

Storage & shelf life

Lyophilized 5-amino-1MQ is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published pharmacokinetic data on 5-amino-1MQ in humans is limited. As a small molecule, it is generally reported to have a plasma half-life on the order of hours in preclinical models.