KPV Reconstitution Calculator

What is KPV?

KPV is a three-amino-acid peptide (lysine-proline-valine) corresponding to the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). Published research has studied KPV for its anti-inflammatory activity in cell and animal models of inflammatory bowel disease, skin inflammation, and other mucosal inflammation contexts. Because it is a very short peptide, KPV has been investigated in both injectable and oral formulations in research settings. KPV is not approved by the FDA for human use. Research-grade KPV sold by chemical supply companies is labeled for laboratory research only.

Common vial sizes

Research vendors typically offer KPV in 5 mg, 10 mg, or 20 mg lyophilized vials. Reconstitution with 2–5 mL of bacteriostatic water is commonly reported.

• 5 mg vial
• 10 mg vial
• 20 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 10 mg vial + 2 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 500 mcg dose = 10 units on a u-100 insulin, 1 ml (100 units) (0.1 mL).
• 10 mg vial + 3 mL bacteriostatic water → 3333.33 mcg/mL concentration.
  A 1000 mcg dose = 30 units on a u-100 insulin, 1 ml (100 units) (0.3 mL).
• 20 mg vial + 5 mL bacteriostatic water → 4000 mcg/mL concentration.
  A 1000 mcg dose = 25 units on a u-100 insulin, 1 ml (100 units) (0.25 mL).
• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 250 mcg dose = 10 units on a u-100 insulin, 1 ml (100 units) (0.1 mL).

Storage & shelf life

Lyophilized KPV is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published pharmacokinetic data on KPV is limited. As a very short peptide, it is expected to have a short plasma half-life.