Tirzepatide Calculator
Dosage and reconstitution math for Tirzepatide. A dual GLP-1 and GIP receptor agonist that simultaneously activates two incretin receptors through a single engineered peptide.
Reconstitution calculator
Pre-filled with common defaults for Tirzepatide. Adjust any field to match your own vial.
Show the math
Enter values above to see the step-by-step math.
Free Illustrated Reconstitution Guide (PDF)
8-step visual walkthrough with photos and tips — from gathering supplies to drawing your dose. Educational only — not medical advice.
Tirzepatide dosage calculator
The Tirzepatide dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. Tirzepatide is commonly sold in 5 mg, 10 mg, 15 mg, 30 mg, 60 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A dual GLP-1 and GIP receptor agonist that simultaneously activates two incretin receptors through a single engineered peptide. Enter your target dose in the calculator above to see the exact number of units to draw.
Tirzepatide dosage chart
| Sample dose | Concentration | Volume to draw | Units on U-100 |
|---|---|---|---|
| 0.38 mg | 5 mg/mL | 0.076 mL | 7.6 |
| 0.75 mg | 5 mg/mL | 0.15 mL | 15 |
| 1.5 mg | 5 mg/mL | 0.3 mL | 30 |
| 3 mg | 5 mg/mL | 0.6 mL | 60 |
| 6 mg | 5 mg/mL | 1.2 mL | 120 |
Tirzepatide and GLP-1 peptides
Tirzepatide is a GLP-1 / GIP dual agonist. A dual GLP-1 and GIP receptor agonist that simultaneously activates two incretin receptors through a single engineered peptide. The same molecule is the active ingredient in Mounjaro and Zepbound, which are FDA-approved prescription medications manufactured by their respective companies. Research-use Tirzepatide is regulated differently and is not approved for human consumption. Other peptides in the GLP-1 class include Semaglutide , and Retatrutide .
How to reconstitute Tirzepatide
Reconstituting Tirzepatide is the same unit-conversion process used for any lyophilized peptide:
- Draw your chosen volume of bacteriostatic water into a syringe.
- Inject the bacteriostatic water slowly down the side of the Tirzepatide vial — do not shoot it directly onto the powder.
- Swirl gently until the powder fully dissolves. Do not shake.
- Store the reconstituted vial refrigerated.
- To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.
For Tirzepatide specifically, 5 mg, 10 mg, 15 mg, 30 mg, 60 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 7.5 mg/mL for the 15 mg vial size.
Tirzepatide half-life and storage
Published pharmacokinetic studies report a terminal half-life of approximately 5 days, attributed to the molecule’s albumin-binding design.
Lyophilized tirzepatide is typically stored refrigerated at 2–8 °C, protected from light. Once reconstituted, published and manufacturer sources commonly report stability of several weeks under refrigeration, depending on buffer and handling.
Common Tirzepatide dosing mistakes
- Confusing mg and mcg. 1 mg = 1,000 mcg. Always convert to the same unit before computing the draw.
- Using a U-40 syringe with U-100 math. Same printed mark, 2.5× the physical volume. Always check the syringe label.
- Not labeling the vial. Write the reconstitution date and concentration on the vial the moment you mix it.
- Under-diluting. If your draw is less than about 1 unit, the volume is too small to read accurately — add more bacteriostatic water next time.