Tirzepatide Reconstitution Calculator

What is Tirzepatide?

Tirzepatide is a synthetic peptide that has been engineered to activate two incretin receptors simultaneously: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the GLP-1 receptor. Published research has studied its dual-agonist pharmacology in the context of glucose regulation, gastric emptying, and energy balance. Like semaglutide, the molecule incorporates a fatty acid linker that extends its circulating half-life through albumin binding. Tirzepatide has been the subject of Phase III clinical programs reported in journals including the New England Journal of Medicine, and has been approved by regulatory agencies under brand names including Mounjaro and Zepbound for use by prescription. Research-grade tirzepatide sold by chemical supply companies is labeled for laboratory use only and is not approved by the FDA for human consumption.

Common vial sizes

Research chemical vendors commonly offer tirzepatide in lyophilized vials ranging from 5 mg to 60 mg. Larger vials are typically reconstituted with proportionally more bacteriostatic water to keep draw volumes manageable.

• 5 mg vial
• 10 mg vial
• 15 mg vial
• 30 mg vial
• 60 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 10 mg vial + 2 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 2500 mcg dose = 50 units on a u-100 insulin, 1 ml (100 units) (0.5 mL).
• 10 mg vial + 2 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 5000 mcg dose = 100 units on a u-100 insulin, 1 ml (100 units) (1 mL).
• 15 mg vial + 3 mL bacteriostatic water → 5000 mcg/mL concentration.
  A 5000 mcg dose = 100 units on a u-100 insulin, 1 ml (100 units) (1 mL).
• 30 mg vial + 3 mL bacteriostatic water → 10000 mcg/mL concentration.
  A 10000 mcg dose = 100 units on a u-100 insulin, 1 ml (100 units) (1 mL).

Storage & shelf life

Lyophilized tirzepatide is typically stored refrigerated at 2–8 °C, protected from light. Once reconstituted, published and manufacturer sources commonly report stability of several weeks under refrigeration, depending on buffer and handling.

Reported half-life

Published pharmacokinetic studies report a terminal half-life of approximately 5 days, attributed to the molecule’s albumin-binding design.