CJC-1295 (no DAC) Reconstitution Calculator

What is CJC-1295 (no DAC)?

CJC-1295 without DAC — sometimes called "Mod GRF (1-29)" or "modified GRF" — is a synthetic analog of the first 29 amino acids of growth hormone releasing hormone (GHRH) with amino acid substitutions that increase stability relative to native GHRH. Published research has studied the molecule for its ability to stimulate pulsatile growth hormone release from the anterior pituitary. It is structurally distinct from CJC-1295 with DAC (drug affinity complex), which carries a maleimide group that binds albumin covalently. CJC-1295 (no DAC) is not approved by the FDA for human use. Research-grade material is sold as a laboratory reagent.

Common vial sizes

Research vendors typically offer CJC-1295 (no DAC) in 2 mg or 5 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

• 2 mg vial
• 5 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 100 mcg dose = 10 units on a u-100 insulin, 1 ml (100 units) (0.1 mL).
• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 200 mcg dose = 20 units on a u-100 insulin, 1 ml (100 units) (0.2 mL).
• 5 mg vial + 3 mL bacteriostatic water → 1666.67 mcg/mL concentration.
  A 200 mcg dose = 12 units on a u-100 insulin, 1 ml (100 units) (0.12 mL).
• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 300 mcg dose = 30 units on a u-100 insulin, 1 ml (100 units) (0.3 mL).

Storage & shelf life

Lyophilized CJC-1295 (no DAC) is typically stored refrigerated at 2–8 °C or frozen for longer storage. Reconstituted solutions are commonly refrigerated and protected from light.

Reported half-life

Published pharmacokinetic data reports a plasma half-life of approximately 30 minutes for CJC-1295 without DAC — substantially shorter than the albumin-binding DAC variant.