MOTS-c Calculator

MOTS-c dosage calculator

The MOTS-c dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. MOTS-c is commonly sold in 5 mg, 10 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, studied for metabolic and AMPK-related signaling. Enter your target dose in the calculator above to see the exact number of units to draw.

MOTS-c dosage chart

MOTS-c and Mitochondrial peptides

MOTS-c is a Mitochondrial-derived peptide. A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, studied for metabolic and AMPK-related signaling. Other peptides in the Mitochondrial class include SS-31 (Elamipretide) .

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded by a short open reading frame within mitochondrial DNA. Published research has characterized MOTS-c as a mitochondrial-derived peptide that has been studied for its roles in metabolic homeostasis, glucose regulation, and AMPK-related signaling in cell and animal models. The published literature on MOTS-c is expanding but still primarily preclinical. MOTS-c is not approved by the FDA for human use. Research-grade MOTS-c is sold as a laboratory reagent only.

See all Mitochondrial peptides →

How to reconstitute MOTS-c

Research vendors typically offer MOTS-c in 5 mg or 10 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

Reconstituting MOTS-c is the same unit-conversion process used for any lyophilized peptide:

1. Draw your chosen volume of bacteriostatic water into a syringe.
2. Inject the bacteriostatic water slowly down the side of the MOTS-c vial — do not shoot it directly onto the powder.
3. Swirl gently until the powder fully dissolves. Do not shake.
4. Store the reconstituted vial refrigerated.
5. To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.

For MOTS-c specifically, 5 mg, 10 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 5 mg/mL for the 10 mg vial size.

MOTS-c half-life and storage

Published pharmacokinetic data on MOTS-c is limited. As a mid-sized peptide without stability modifications, it is generally reported to have a plasma half-life on the order of a few hours.

Lyophilized MOTS-c is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.

Common MOTS-c dosing mistakes

Most MOTS-c draw errors are unit errors, not arithmetic errors: confusing mg with mcg (1 mg = 1,000 mcg), or reading a U-40 syringe with U-100 math — the same printed mark holds 2.5× the volume. Two more worth avoiding: leaving the vial unlabeled, so the concentration and reconstitution date are lost, and under-diluting to the point where the draw is under about one unit and can no longer be read accurately.

Each of these is covered in full in the guides: reconstitution math from first principles, U-100 vs U-40 syringes, storage and shelf life, and how to reconstitute peptides.

MOTS-c stacks

MOTS-c is one of the ingredients in what is commonly referred to as the Longevity stack . These are terms used in online peptide communities to describe specific combinations. See the stack pages for the full composition and calculator links.