MOTS-c Calculator
Dosage and reconstitution math for MOTS-c. A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, studied for metabolic and AMPK-related signaling.
Reconstitution calculator
Pre-filled with common defaults for MOTS-c. Adjust any field to match your own vial.
Show the math
Enter values above to see the step-by-step math.
Free Illustrated Reconstitution Guide (PDF)
8-step visual walkthrough with photos and tips — from gathering supplies to drawing your dose. Educational only — not medical advice.
MOTS-c dosage calculator
The MOTS-c dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. MOTS-c is commonly sold in 5 mg, 10 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, studied for metabolic and AMPK-related signaling. Enter your target dose in the calculator above to see the exact number of units to draw.
MOTS-c dosage chart
| Sample dose | Concentration | Volume to draw | Units on U-100 |
|---|---|---|---|
| 0.19 mg | 3.33333 mg/mL | 0.057 mL | 5.7 |
| 0.38 mg | 3.33333 mg/mL | 0.114 mL | 11.4 |
| 0.75 mg | 3.33333 mg/mL | 0.225 mL | 22.5 |
| 1.5 mg | 3.33333 mg/mL | 0.45 mL | 45 |
| 3 mg | 3.33333 mg/mL | 0.9 mL | 90 |
MOTS-c and Mitochondrial peptides
MOTS-c is a Mitochondrial-derived peptide. A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, studied for metabolic and AMPK-related signaling. Other peptides in the Mitochondrial class include SS-31 (Elamipretide) .
See all Mitochondrial peptides →
How to reconstitute MOTS-c
Reconstituting MOTS-c is the same unit-conversion process used for any lyophilized peptide:
- Draw your chosen volume of bacteriostatic water into a syringe.
- Inject the bacteriostatic water slowly down the side of the MOTS-c vial — do not shoot it directly onto the powder.
- Swirl gently until the powder fully dissolves. Do not shake.
- Store the reconstituted vial refrigerated.
- To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.
For MOTS-c specifically, 5 mg, 10 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 5 mg/mL for the 10 mg vial size.
MOTS-c half-life and storage
Published pharmacokinetic data on MOTS-c is limited. As a mid-sized peptide without stability modifications, it is generally reported to have a plasma half-life on the order of a few hours.
Lyophilized MOTS-c is typically stored refrigerated or frozen. Reconstituted solutions are commonly refrigerated and protected from light.
Common MOTS-c dosing mistakes
- Confusing mg and mcg. 1 mg = 1,000 mcg. Always convert to the same unit before computing the draw.
- Using a U-40 syringe with U-100 math. Same printed mark, 2.5× the physical volume. Always check the syringe label.
- Not labeling the vial. Write the reconstitution date and concentration on the vial the moment you mix it.
- Under-diluting. If your draw is less than about 1 unit, the volume is too small to read accurately — add more bacteriostatic water next time.
MOTS-c stacks
MOTS-c is one of the ingredients in what is commonly referred to as the Longevity stack . These are terms used in online peptide communities to describe specific combinations. See the stack pages for the full composition and calculator links.