Tesamorelin Reconstitution Calculator

What is Tesamorelin?

Tesamorelin is a synthetic analog of growth hormone releasing hormone (GHRH) with an N-terminal modification (a trans-3-hexenoic acid group) that increases its stability relative to native GHRH and sermorelin. Published clinical research has studied tesamorelin for its effects on visceral adipose tissue and has been the subject of trials in HIV-associated lipodystrophy. Tesamorelin has been approved by the FDA under the brand name Egrifta for reduction of excess abdominal fat in HIV patients with lipodystrophy. Research-grade tesamorelin from chemical supply companies is labeled for laboratory use only and is distinct from the approved pharmaceutical product.

Common vial sizes

Research vendors typically offer tesamorelin in 2 mg, 5 mg, or 10 mg lyophilized vials. Reconstitution with 2–3 mL of bacteriostatic water is commonly reported.

• 2 mg vial
• 5 mg vial
• 10 mg vial

Reconstitution examples

Worked examples showing exactly what a given vial, bacteriostatic water volume, and target dose produce in syringe units. All math is from the same calculator above.

• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 1000 mcg dose = 40 units on a u-100 insulin, 1 ml (100 units) (0.4 mL).
• 5 mg vial + 2 mL bacteriostatic water → 2500 mcg/mL concentration.
  A 2000 mcg dose = 80 units on a u-100 insulin, 1 ml (100 units) (0.8 mL).
• 10 mg vial + 3 mL bacteriostatic water → 3333.33 mcg/mL concentration.
  A 2000 mcg dose = 60 units on a u-100 insulin, 1 ml (100 units) (0.6 mL).
• 2 mg vial + 2 mL bacteriostatic water → 1000 mcg/mL concentration.
  A 1000 mcg dose = 100 units on a u-100 insulin, 1 ml (100 units) (1 mL).

Storage & shelf life

Lyophilized tesamorelin is typically stored refrigerated. The approved branded product Egrifta has published stability data for the reconstituted solution, typically in the range of several hours at room temperature or longer under refrigeration.

Reported half-life

Published pharmacokinetic studies report a plasma half-life of approximately 26 minutes for tesamorelin.