Semaglutide Calculator
Dosage and reconstitution math for Semaglutide. A GLP-1 receptor agonist that mimics the GLP-1 incretin hormone and binds to GLP-1 receptors in pancreatic and neural tissue.
Reconstitution calculator
Pre-filled with common defaults for Semaglutide. Adjust any field to match your own vial.
Show the math
Enter values above to see the step-by-step math.
Free Illustrated Reconstitution Guide (PDF)
8-step visual walkthrough with photos and tips — from gathering supplies to drawing your dose. Educational only — not medical advice.
Semaglutide dosage calculator
The Semaglutide dosage calculator above converts a target dose into exact syringe units based on your vial size and how much bacteriostatic water you used to reconstitute it. Semaglutide is commonly sold in 2 mg, 3 mg, 5 mg, 10 mg vials. The calculator supports both U-100 and U-40 insulin syringes and flags draws that are too large for the syringe barrel or too small to measure accurately. A GLP-1 receptor agonist that mimics the GLP-1 incretin hormone and binds to GLP-1 receptors in pancreatic and neural tissue. Enter your target dose in the calculator above to see the exact number of units to draw.
Semaglutide dosage chart
| Sample dose | Concentration | Volume to draw | Units on U-100 |
|---|---|---|---|
| 100 mcg | 2.5 mg/mL | 0.04 mL | 4 |
| 200 mcg | 2.5 mg/mL | 0.08 mL | 8 |
| 400 mcg | 2.5 mg/mL | 0.16 mL | 16 |
| 800 mcg | 2.5 mg/mL | 0.32 mL | 32 |
| 1600 mcg | 2.5 mg/mL | 0.64 mL | 64 |
Semaglutide and GLP-1 peptides
Semaglutide is a GLP-1 receptor agonist. A GLP-1 receptor agonist that mimics the GLP-1 incretin hormone and binds to GLP-1 receptors in pancreatic and neural tissue. The same molecule is the active ingredient in Ozempic and Wegovy and Rybelsus, which are FDA-approved prescription medications manufactured by their respective companies. Research-use Semaglutide is regulated differently and is not approved for human consumption. Other peptides in the GLP-1 class include Tirzepatide , and Retatrutide .
How to reconstitute Semaglutide
Reconstituting Semaglutide is the same unit-conversion process used for any lyophilized peptide:
- Draw your chosen volume of bacteriostatic water into a syringe.
- Inject the bacteriostatic water slowly down the side of the Semaglutide vial — do not shoot it directly onto the powder.
- Swirl gently until the powder fully dissolves. Do not shake.
- Store the reconstituted vial refrigerated.
- To dose, calculate your draw volume: divide your target dose by the concentration (vial mg ÷ water mL = mg/mL). The calculator above does this automatically.
For Semaglutide specifically, 2 mg, 3 mg, 5 mg, 10 mg vials are common. A typical reconstitution adds 2 mL of bacteriostatic water, producing a concentration of 2.5 mg/mL for the 5 mg vial size.
Semaglutide half-life and storage
Published pharmacokinetic studies report a terminal half-life of approximately 7 days in humans, reflecting albumin binding and slow receptor-mediated clearance.
Lyophilized semaglutide is typically stored refrigerated at 2–8 °C and protected from light. Reconstituted solutions are generally reported in manufacturer literature to remain stable for several weeks under refrigeration, with exact figures varying by buffer and vial conditions.
Common Semaglutide dosing mistakes
- Confusing mg and mcg. 1 mg = 1,000 mcg. Always convert to the same unit before computing the draw.
- Using a U-40 syringe with U-100 math. Same printed mark, 2.5× the physical volume. Always check the syringe label.
- Not labeling the vial. Write the reconstitution date and concentration on the vial the moment you mix it.
- Under-diluting. If your draw is less than about 1 unit, the volume is too small to read accurately — add more bacteriostatic water next time.